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Wegovy
What is Wegovy?
Wegovy (semaglutide) injection is a prescription medicine used for weight loss in obese adults and teenagers, or overweight adults with other weight-related medical issues. Wegovy works by regulating appetite and reducing calorie intake, leading to weight loss and helping with weight management.
Wegovy belongs to the class of drugs called GLP-1 receptor agonists. GLP-1 receptor agonists are a manufactured version of GLP-1, a naturally occurring hormone in the body that acts in several areas in the brain to regulate food intake. When Wegovy is administered, it activates the GLP-1 receptors in the brain. This lowers appetite, reducing the calories consumed, leading to weight loss.
This medicine should be used together with a decreased-calorie meal plan and increased physical activity to help weight management.
Wegovy is given as an injection under the skin (subcutaneous injection) once a week.
What is Wegovy used for?
Wegovy is an FDA-approved anti-obesity medicine to be used by people 12 years and older for chronic weight management when used together with a reduced-calorie diet and increased physical activity.
Wegovy is indicated for use in:
Adults:
- Obese (BMI of 30 kg/m2 or greater)
- Overweight (BMI of 27 kg/m2 or greater) and have medical problems (e.g.high blood pressure, type 2 diabetes, or high cholesterol) due to your weight.
Pediatric (12 years and older):
- Obese (initial BMI 95th percentile or greater for age and sex)
Wegovy contains semaglutide which is the same active ingredient in Ozempic and Rybelsus, therefore these products should not be used together. Ozempic (subcutaneous weekly injection) and Rybelsus (once-a-day tablet) are used lower blood sugar levels for type two diabetic patients. Ozempic is also used to lower the risk of major cardiovascular events for some type 2 diabetic patients.
Warnings
Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath. In studies with rodents, Wegovy and medicines that work like Wegovy caused thyroid tumors, including thyroid cancer. It is not known if this medicine will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.
You should not use this medicine if you have tumors in your glands called multiple endocrine neoplasia type 2 (MEN 2), or a personal or family history of medullary thyroid cancer (MTC).
Before taking this medicine
You should not use Wegovy if you are:
- allergic to it or any of the ingredients. See the end of this page for a complete list of ingredients. Symptoms of a serious allergic reaction include swelling of your face, lips, tongue, or throat, problems breathing or swallowing, severe rash or itching, feeling dizzy or lightheaded, and a very rapid heartbeat.
- multiple endocrine neoplasia type 2 (tumors in your glands); or
- a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer).
Tell your doctor if you have ever had:
- a stomach or intestinal disorder;
- pancreatitis;
- kidney disease;
- eye problems caused by diabetes (diabetic retinopathy);
- have or have had depression or suicidal thoughts, or other mental health issues.
In animal studies, semaglutide caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people. Ask your doctor about your risk.
What happens if I miss a dose?
- Use the medicine as soon as possible and then return to your regular schedule. But If your next dose is due in less than two days (48 hours), skip the missed dose and return to your regular schedule.
- Call your doctor if you miss more than two doses in a row of Wegovy. You may need to restart the medicine at a lower dose to avoid stomach problems.
- Do not use two doses of semaglutide at one time.
What happens if I overdose?
- Seek emergency medical attention.
- Overdose may cause severe nausea, vomiting, or low blood sugar.
What strengths is Wegovy available in ?
Wegovy is available in five strengths:
- Wegovy 0.25 mg (semaglutide) pen
- Wegovy 0.5 mg (semaglutide) pen
- Wegovy 1 mg (semaglutide) pen
- Wegovy 1.7 mg (semaglutide) pen
- Wegovy 2.4 mg(semaglutide) pen
General information
- Do not use different brands of semaglutide at the same time.
- Blood sugar can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals.
- Low blood sugar (hypoglycemia) can make you feel very hungry, dizzy, irritable, or shaky. To quickly treat hypoglycemia, eat or drink hard candy, crackers, raisins, fruit juice, or non-diet soda. Your doctor may prescribe glucagon injection in case of severe hypoglycemia.
- Tell your doctor if you have frequent symptoms of high blood sugar (hyperglycemia), such as increased thirst or urination. Ask your doctor before changing your dose or medication schedule.
- Your treatment may also include diet, exercise, weight control, medical tests, and special medical care.
- You may get dehydrated during prolonged illness. Call your doctor if you are sick with vomiting or diarrhea or if you eat or drink less than usual.
What should I avoid while using Wegovy?
Never share an injection pen, even if you changed the needle. Sharing this device can pass infection or disease from person to person.
Wegovy side effects
Get emergency medical help if you have signs of an allergic reaction: hives, itching; dizziness, fast heartbeats, difficulty breathing; swelling of your face, lips, tongue, or throat.
Semaglutide may cause serious side effects. Call your doctor at once if you have:
- vision changes;
- pounding heartbeats or fluttering in your chest;
- a light-headed feeling, like you might pass out;
- symptoms of pancreatitis–severe pain in your upper stomach spreading to your back, nausea with or without vomiting, fast heart rate;
- gallbladder problems–upper stomach pain, fever, clay-colored stools, jaundice (yellowing of the skin or eyes);
- low blood sugar–headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery;
- stomach flu symptoms–stomach cramps, vomiting, loss of appetite, diarrhea (may be watery or bloody).
Common side effects of semaglutide may include:
- low blood sugar (in people with type 2 diabetes);
- upset stomach, heartburn, burping, gas, bloating;
- nausea, vomiting, stomach pain, loss of appetite;
- diarrhea, constipation;
- runny nose or sore throat;
- stomach flu symptoms; o
- headache, dizziness, tiredness.
What other drugs will affect Wegovy?
Wegovy can slow your digestion, and it may take longer for your body to absorb any medicines you take by mouth.
Tell your doctor about all your other medicines, especially insulin or other diabetes medicine, such as dulaglutide, exenatide, liraglutide, Byetta, Trulicity, Victoza, and others.
Other drugs may affect Wegovy, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Storage
Wegovy single-dose pen:
- Wegovy should be stored in refrigerator from 2°C to 8°C (36°F to 46°F).
- If needed (prior to cap removal), the pen can be kept from 8°C to 30°C (46°F to 86°F) for up to 28 days.
- Do not freeze.
- Protect Wegovy from light, and it must be kept in the original carton until time of administration. Discard the Wegovy pen after use.
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