What is Mounjaro?

Mounjaro is a once-weekly injection that is FDA approved to be used to decrease blood sugar (blood glucose) in adults who have type 2 diabetes. It should be used together with diet and exercise. Mounjaro has also been shown in clinical trials to be useful for weight loss, however it is currently not an FDA approved weight loss drug.

Diabetes is a long term condition when your blood sugars (HbA1c) become too high because the body does not produce or use insulin normally.  Overtime high blood sugars can cause serious health problems including heart disease, vision loss and kidney disease.

Mounjaro works to reduce blood sugar levels by increasing your insulin production and also lowering the amount of sugar your liver makes. It also slows the rate food passes through your body which makes you feel full longer.

Mounjaro (Tirzepatide) is the first dual GIP/GLP-1 receptor agonist which means it works on the glucose-dependent insulinotropic polypeptide (GIP) receptors and the glucagon-like peptide-1 (GLP-1) receptors.

Mounjaro can be used as a single therapy or with other diabetes medicines including metformin, sulfonylureas or SGLT2 inhibitors.

It is not known if this medicine can be used in people who have had pancreatitis.

Mounjaro is not for use in people with type 1 diabetes.

 Is Mounjaro used for weight loss?

• Mounjaro has also shown to help lose weight in overweight patients. It is currently in Phase 3 clinical trials for weight loss in adults who are overweight, obese or have weight related health issues. Mounjaro has received FDA  Fast Track designation to speed up its path for FDA submission for treating  adults with obesity, or overweight with weight-related health conditions.
• In the SURMOUNT-1 clinical trial the average weight loss after 72 weeks was 15% for the 5mg dose, 19.5% for the 10mg dose and 20.9% for the 15mg dose.
• Mounjaro is not FDA approved as a weight loss medication.

Before using Mounjaro

• Tell your doctor and pharmacist if you are allergic to Mounjaro, any other medications, or any of the ingredients in this injection. Ask your pharmacist or check the Medication Guide  for a list of the ingredients.
• Tell your doctor if you have or have ever had pancreas or kidney disease, stomach problems such as difficulty digesting food, or history of diabetic retinopathy.
• Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking this medicine, call your doctor.

What should I do if I miss a dose?

Take the missed dose as soon as you remember it within 4 days after the missed dose. However, if more than 4 days have passed, skip the missed dose and continue your regular dosing schedule. Do not inject two doses within 3 days of each other.

What should I do in case of overdose?

In case of overdose If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

What are the side effects of Mounjaro?

Mounjaro may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea
• diarrhea
• decreased appetite
• vomiting
• constipation
• upset stomach

Some side effects can be serious. If you experience any of these symptoms or those listed in the Important Information section, stop taking this medicine and call your doctor immediately:

• stomach pain that will not go away (and may radiate to the back) with or without vomiting

Mounjaro may cause hypoglycemia (low blood sugar). Signs and symptoms of low blood sugar may include dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heart rate and feeling jittery.This medicine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Interactions

Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Birth control pills may not work as well while receiving this medicine. Your doctor may suggest you use another form of birth control for 4 weeks after starting Mounjaro and for 4 weeks after each dose change.

Taking Mounjaro with other medicines to treat diabetes like insulin or sulfonylureas may increase your risk of hypoglycemia. Talk to your doctor and pharmacist about low blood sugar and how to manage it.

This list is not complete. Many other drugs may interact with Mounjaro, including prescription and over-the-counter medicines, vitamins, and herbal products. To check for interactions with this medicine click the link below.

Storage

Mounjaro should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). Keep it in the original carton until use to protect from light. Single-dose pens can be stored at room temperature for 21 days, if needed. Store your medication only as directed. Make sure you understand how to store your medication properly.

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